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Tilmic Oral Solution For  Cattle, Pigs, Poultry (1000ML)

Tilmic Oral Solution For Cattle, Pigs, Poultry (1000ML)

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Tilmicosin 250 mg Oral Solution, 1000 ml


1 ml of the drug contains:
tilmicosin — 250 mg
Excipients: disodium edetate, propyl gallate, orthophosphoric acid, highly purified water

The liquid is light yellow, homogeneous, transparent.

Pharmacological properties
Tilmicosin is a semi-synthetic antibiotic from the group of macrolides, which acts bacteriostatically at low concentrations, and bactericidal at high concentrations. Active against gram-positive microorganisms — Clostridium perfringens, Actinomyces spp., Corynebacterium spp., Staphylococcus aureus, Arcanobacterium pyogenes, gram-negative microorganisms — Pasteurella spp., Haemophilus spp., Campylobacter spp., Ornithobacterium rhinotracheale, Actinobacillus pleuropneumoniae, Mannheimia haemolitica, etc. and Mycoplasma spp. The mechanism of action consists in blocking protein synthesis in bacterial cells as a result of the formation of a complex with 50S subunits of ribosomes.
After oral administration, tilmicosin is quickly and almost completely absorbed from the gastrointestinal tract, passes from the blood plasma to the lungs. As a result, a low level of tilmicosin is observed in the blood serum, and the highest level is observed in the lungs and macrophages of the lung tissue, which is recorded after 6 hours. Therapeutic concentrations of the drug in all organs and tissues of the body are maintained for 48 hours.
In chickens, tilmicosin reaches a therapeutic concentration in the air sacs in less than 6 hours, in turkeys it is concentrated in the lungs and air sacs, in calves it is observed in the lungs after 6 hours and is retained for 60 hours, and its high concentrations are found in the liver and kidneys , in pigs it reaches its maximum concentration in the lungs.
It is excreted from the body mainly with bile, a small amount with urine.

Treatment of animals for respiratory diseases caused by microorganisms sensitive to tilmicosin:
calves under 3 months of age — Mycoplasma bovis, M. dispar, Mannheimia haemolitica, Arcanobacterium pyogenes, Pasteurella multocida, P. haemolytica, etc.;
pigs — Mycoplasma hyopneumoniae, Pasteurella multocida, Actinobacillus pleuropneumoniae, Arcanobacterium pyogenes, etc.;
chickens (broilers, repair young, parent flock), turkeys — Mycoplasma gallisepticum, M. synoviae, Ornithobacterium rhinotracheale, Pasteurella multocida, etc.

Do not prescribe to animals with increased sensitivity to tilmicosin, horses, ruminants with functionally developed foreguts, laying hens whose eggs are consumed by humans.
Do not use when resistant strains of pathogenic bacteria resistant to macrolides are detected.
Do not use simultaneously with antibiotics of the aminoglycoside series, other macrolides and ionoform coccidiostats, as well as in a mixture with feeds containing bentonites.

Method of application and dosage
The drug is given orally: to birds - with drinking water, to pigs, calves - with milk, milk substitute or liquid feed. Drug solutions are prepared immediately before use. Dose depending on the method of use (group or individual):
pigs — 80 ml of the drug per 100 l of drinking water (daily dose of tilmicosin — 15-20 mg per 1 kg of body weight), course — 5 days;
chickens (broilers, repair young, parent flock), turkeys — 30 ml of the drug per 100 liters of drinking water (daily dose of tilmicosin: chickens — 15-20 mg per 1 kg of body weight, turkeys — 10-27 mg per 1 kg of body weight) , course — 3 days;
calves — 1 ml of the drug per 20 kg of body weight 2 times a day (12.5 mg of tilmicosin per 1 kg of body weight), course — 3-5 days.

When using the drug in the recommended doses, side effects and complications are usually not observed. Sometimes there are short-term disorders of the gastrointestinal tract.
Due to the possible development of resistant strains of bacteria, the drug, like all macrolides, should be used only after carrying out tests for the sensitivity of microorganisms to tilmicosin.
After the last use of the drug, chickens can be slaughtered for meat after 12 days, pigs - after 14 days, broiler chickens, turkeys - after 19 days, calves - after 42 days. Meat obtained before the specified term is disposed of or fed to non-productive animals, depending on the opinion of the veterinarian.

Storage conditions
In a dry, dark place inaccessible to children at temperatures from +10 to +30 °C.
After opening the bottle, the drug should be stored at a temperature of +5 to +25 °C and used within 90 days, aqueous solutions of the drug should be used within 24 hours.

Expiration date
3 years.