Description
Homogeneous suspension of yellowish color.
Storage
1 ml of the drug contains the active ingredient:
megestrol acetate - 40.0 mg.
Excipients: polyethylene glycol, polysorbate, xanthan gum, sodium benzoate, citric acid, sodium citrate, sucrose.
Pharmacological properties
Megestrol acetate is a synthetic progestogen that blocks the secretion of gonadotropic follicle-stimulating (FSH) and luteinizing (LH) hormones produced by the anterior lobe of the pituitary gland. With a lack of these hormones, the maturation of follicles in the ovaries of females is delayed, as a result of which estrus and sexual desire in animals cease. By suppressing the secretion of gonadotropic hormones and delaying ovulation, megestrol provides an antigonadotropic effect, clinically manifested by the delay of estrus, and a progestagen effect through a direct effect on the endometrium of the uterus, which causes its secretory phase, thanks to which the implantation of the embryo is inhibited and the contraceptive properties of the drug are ensured.
In males, under the influence of megestrol, the synthesis of testosterone is blocked, as a result of which their sexual activity decreases and related to it: anxiety, increased excitability and aggressive behavior.
Megestrol acetate is quickly absorbed in the intestines and after three hours reaches the maximum concentration in the blood plasma. It is metabolized in the liver and excreted from the body in the form of metabolites, mainly with urine within 1-2 days.
Application
Cats and bitches for the purpose of preventing or stopping oestrus and/or preventing unwanted pregnancy.
Cats and dogs with the purpose of suppressing sexual drive, as well as correcting unwanted behavior (increased excitability, aggressiveness, tendency to wander, etc.). Pigs with the purpose of preventing estrus and/or synchronizing sexual desire.
Dosage
Orally with food or forced directly into the mouth on the root of the tongue:
cats: to prevent estrus - 4 drops (0.125 ml) every two weeks, or 2 drops (0.0625 ml) every week, but not more than 18 months; to stop estrus - 4 drops (0.125 ml) every day, for 3-5 days, until the manifestations of estrus disappear (starting no later than on the third day from the moment signs of sexual arousal appear); as a contraceptive - 4 drops (0.125 ml), on the first day after mating;
bitches: to prevent estrus - 4 drops (0.125 ml) per 10 kg of body weight daily, starting 7-10 days before its onset, but no more than four weeks; to stop estrus - 8 drops (0.5 ml) per 10 kg of body weight, during the first three days from the moment of signs of sexual arousal and 4 drops (0.125 ml) during the following days; as a contraceptive - 8 drops (0.5 ml) per 10 kg of body weight, daily in the first two days after mating;
for sows: to synchronize sexual desire in primary sows - 4 drops (0.125 ml) per 10 kg of body weight every day for 14 days. Repair pigs are given the drug in a double dose. After withdrawal of the drug, the phase of sexual arousal occurs simultaneously in all sows after 42-43 days; to prevent sexual arousal in fattening pigs, 2 weeks after the previous sexual arousal, 8 drops (0.5 ml) per 10 kg of body weight are applied daily, 10-14 days in a row;
cats: to calm sexual arousal - 4 drops (0.125 ml) during the first 5-7 days with subsequent repetition in the same dose once every 7 days;
dogs: to calm down during sexual arousal - 8 drops (0.5 ml) per 10 kg of body weight, daily for the first 5 days, with a further two-fold reduction of the daily dose (to 0.25 ml per 10 kg of body weight) during another week until complete comfort.
Contraindication
Do not use the drug in diseases of the reproductive system (pyometra, metritis, endometritis, etc.), breast tumors, diabetes, sexually immature animals, pregnant animals, and lactating animals. It is not recommended to use the drug if more than 3 days have passed since the onset of estrus and young animals are in their first estrus due to the difficulty of determining the beginning of the cycle.
Reservation
Slaughter of animals for meat (pigs) is allowed 14 days after the last use of the drug. The meat obtained by the specified deadline is disposed of or fed to non-productive animals depending on the opinion of the veterinary medicine doctor.
With long-term use of the drug, a change in character, an increase in mammary glands, an increase in appetite and a related increase in the animal's body weight are possible.
Storage
Dry, dark place, inaccessible to children, at a temperature from 4°C to 25°C.
Expiration date
2 years.
The shelf life after opening (selection) is 1 month, provided it is tightly closed and stored at a temperature of 4°C to 8°C.
Manufacturer: "Brovafarma®" UKRAINE
FREE SHIPPING TO USA AND UK
Homogeneous suspension of yellowish color.
Storage
1 ml of the drug contains the active ingredient:
megestrol acetate - 40.0 mg.
Excipients: polyethylene glycol, polysorbate, xanthan gum, sodium benzoate, citric acid, sodium citrate, sucrose.
Pharmacological properties
Megestrol acetate is a synthetic progestogen that blocks the secretion of gonadotropic follicle-stimulating (FSH) and luteinizing (LH) hormones produced by the anterior lobe of the pituitary gland. With a lack of these hormones, the maturation of follicles in the ovaries of females is delayed, as a result of which estrus and sexual desire in animals cease. By suppressing the secretion of gonadotropic hormones and delaying ovulation, megestrol provides an antigonadotropic effect, clinically manifested by the delay of estrus, and a progestagen effect through a direct effect on the endometrium of the uterus, which causes its secretory phase, thanks to which the implantation of the embryo is inhibited and the contraceptive properties of the drug are ensured.
In males, under the influence of megestrol, the synthesis of testosterone is blocked, as a result of which their sexual activity decreases and related to it: anxiety, increased excitability and aggressive behavior.
Megestrol acetate is quickly absorbed in the intestines and after three hours reaches the maximum concentration in the blood plasma. It is metabolized in the liver and excreted from the body in the form of metabolites, mainly with urine within 1-2 days.
Application
Cats and bitches for the purpose of preventing or stopping oestrus and/or preventing unwanted pregnancy.
Cats and dogs with the purpose of suppressing sexual drive, as well as correcting unwanted behavior (increased excitability, aggressiveness, tendency to wander, etc.). Pigs with the purpose of preventing estrus and/or synchronizing sexual desire.
Dosage
Orally with food or forced directly into the mouth on the root of the tongue:
cats: to prevent estrus - 4 drops (0.125 ml) every two weeks, or 2 drops (0.0625 ml) every week, but not more than 18 months; to stop estrus - 4 drops (0.125 ml) every day, for 3-5 days, until the manifestations of estrus disappear (starting no later than on the third day from the moment signs of sexual arousal appear); as a contraceptive - 4 drops (0.125 ml), on the first day after mating;
bitches: to prevent estrus - 4 drops (0.125 ml) per 10 kg of body weight daily, starting 7-10 days before its onset, but no more than four weeks; to stop estrus - 8 drops (0.5 ml) per 10 kg of body weight, during the first three days from the moment of signs of sexual arousal and 4 drops (0.125 ml) during the following days; as a contraceptive - 8 drops (0.5 ml) per 10 kg of body weight, daily in the first two days after mating;
for sows: to synchronize sexual desire in primary sows - 4 drops (0.125 ml) per 10 kg of body weight every day for 14 days. Repair pigs are given the drug in a double dose. After withdrawal of the drug, the phase of sexual arousal occurs simultaneously in all sows after 42-43 days; to prevent sexual arousal in fattening pigs, 2 weeks after the previous sexual arousal, 8 drops (0.5 ml) per 10 kg of body weight are applied daily, 10-14 days in a row;
cats: to calm sexual arousal - 4 drops (0.125 ml) during the first 5-7 days with subsequent repetition in the same dose once every 7 days;
dogs: to calm down during sexual arousal - 8 drops (0.5 ml) per 10 kg of body weight, daily for the first 5 days, with a further two-fold reduction of the daily dose (to 0.25 ml per 10 kg of body weight) during another week until complete comfort.
Contraindication
Do not use the drug in diseases of the reproductive system (pyometra, metritis, endometritis, etc.), breast tumors, diabetes, sexually immature animals, pregnant animals, and lactating animals. It is not recommended to use the drug if more than 3 days have passed since the onset of estrus and young animals are in their first estrus due to the difficulty of determining the beginning of the cycle.
Reservation
Slaughter of animals for meat (pigs) is allowed 14 days after the last use of the drug. The meat obtained by the specified deadline is disposed of or fed to non-productive animals depending on the opinion of the veterinary medicine doctor.
With long-term use of the drug, a change in character, an increase in mammary glands, an increase in appetite and a related increase in the animal's body weight are possible.
Storage
Dry, dark place, inaccessible to children, at a temperature from 4°C to 25°C.
Expiration date
2 years.
The shelf life after opening (selection) is 1 month, provided it is tightly closed and stored at a temperature of 4°C to 8°C.
Manufacturer: "Brovafarma®" UKRAINE
FREE SHIPPING TO USA AND UK