Onsior - tablets are an anti-inflammatory and pain-relieving drug, which is recommended for the treatment of various inflammatory and pain syndromes, including acute and chronic diseases of the musculoskeletal system (arthritis, arthrosis, synovitis, dislocations), inflammatory diseases of soft tissues, as well as in postoperative and cats
I. General information
Trade name of the drug: Onsior tablets (Onsior tablets).
International nonproprietary name: robenacoxib.
Pharmaceutical form: pills for oral use.
Onsior contains robenacoxib as an active substance.
The drug is produced in two modifications:
Onsior tablets for cats containing robenacoxib - 6 mg/tablet.
Onsior tablets for dogs in 4 doses containing robenacoxib: 5 mg/tab., 10 mg/tab., 20 mg/tab. or 40 mg/tablet.
As auxiliary substances, the Onsior preparation contains: yeast, microcrystalline cellulose, identical beef flavoring (in "Onsior tablets for dogs"), powdered cellulose (in "Onsior tablets for dogs"), povidone (K-30), crospovidone, anhydrous silicon dioxide and magnesium stearate.
In appearance, the drug is round tablets from beige to brown in color.
Onsior tablets for cats and Onsior tablets for dogs 5 mg are imprinted NA on one side and imprinted AK on the other side;
Onsior Tablets for Dogs 10 mg - Imprint NA on one side and Imprint BE on the other side, Onsior™ Tablets for Dogs 20 mg - Imprint NA on one side and Imprint CD on the other side and Onsior™ Tablets for Dogs 40 mg - Imprint NA on one side side to side and TSK print on the other side.
The shelf life of the medicinal product, subject to compliance with the conditions of storage in the closed packaging of the manufacturer, is 4 years from the date of manufacture.
It is forbidden to use Onsior tablets after the expiry date.
Onsior tablets for cats are available in packs of 6 tablets in blisters made of aluminum foil, placed in 1, 2, 5 or 10 pieces in cardboard packs together with instructions for use.
Onsior tablets for dogs are available in packs of 7 tablets in blisters made of aluminum foil, 1, 2, 4 or 10 pieces are placed in cardboard packs together with instructions for use. food and feed, at a temperature from 0°C to 25°C in places inaccessible to children.
II. Pharmacological properties
Onsior tablets belong to non-steroidal anti-inflammatory drugs.
Robenacoxib, included in the drug, is a non-steroidal anti-inflammatory agent of the coxib group, is a selective specific inhibitor of COX-2 and has anti-inflammatory and analgesic effects.
COX is presented in two forms: COX-1 – the constitutive form of the enzyme – performs protective functions, including in the gastrointestinal tract and kidneys; COX-2, the inducible form of the enzyme, is responsible for the production of mediators, including PHEg, that cause pain, inflammation, and fever.
When administered orally, robenacoxib is rapidly absorbed in the intestine, entering the systemic bloodstream and most organs and tissues; more than 99% of robenacoxib is bound to plasma proteins. Its maximum concentration in plasma is noted after 0.5 hours, bioavailability is 49% in cats and 62% in dogs when using tablets with food and 84% without food. Robenacoxib is metabolized in the liver, excreted mainly with bile (about 70% in cats and about 65% in dogs) and partially - with urine; the elimination half-life from the body of dogs is about 1.2 hours, cats - 1.7 hours.
According to the level of impact on the body, Onsior belongs to moderately dangerous substances.
III. Application procedure
Onsior tablets are prescribed to dogs and cats as an anti-inflammatory and pain-relieving drug for inflammatory and pain syndromes of various origins, including acute and chronic diseases of the musculoskeletal system (arthritis, arthrosis, synovitis, dislocations), inflammatory diseases of soft tissues, and also as an anti-inflammatory drug in the postoperative period.
It is forbidden to use Onsior for animals in a state of dehydration, hypovolemia and hypotension, as well as for animals weighing less than 2.5 kg. In case of extreme need, the prescription of a medicinal product to such animals is carried out under the constant supervision of a veterinarian.
Contraindication to use is the individual increased sensitivity of the animal to the components of the drug.
The drug should not be used in animals with severe heart, kidney and liver failure.
It is recommended to give the drug separately from feeding, but if necessary, the drug can be given together with food. Tablets should not be crushed or broken.
Onsior tablets are used in cats during surgery 30 minutes before anesthesia in a dose of 1-2.4 mg per 1 kg of the animal's weight; treatment can be continued for a period of up to 2 days after surgery; for diseases of the musculoskeletal system, the drug is used for up to 6 days.
Onsior tablets for dogs are used 30 minutes before or after feeding in a dose of 1-2 mg per 1 kg of animal weight. The course of treatment is determined by a veterinarian. As a rule, the duration
Side effects
When using Onsior tablets in accordance with this instruction, side effects and complications in animals, as a rule, are not observed. Cats may experience gastrointestinal disturbances (vomiting, soft stools, or diarrhea) and these symptoms resolve spontaneously and do not require medication. With individual hypersensitivity of the animal to the drug and the appearance of allergic reactions, the use of the drug is stopped and the animal is prescribed antihistamines and symptomatic agents.
Contraindications
It is forbidden to use Onsior tablets in animals in a state of dehydration, hypovolemia and hypotension, as well as in animals weighing less than 2.5 kg. If it is absolutely necessary to prescribe a medicinal product to such animals, treatment is carried out under the constant supervision of a veterinarian. Contraindication to use is the individual hypersensitivity of the animal to the components of the drug. Do not use the drug in animals with severe cardiac, renal and hepatic insufficiency.
Special instructions
Onsior tablets should not be used simultaneously with other non-steroidal anti-inflammatory drugs and within 24 hours after their withdrawal, diuretics, as well as ACE inhibitors and other drugs with a high degree of binding to blood serum proteins due to the likelihood of mutual enhancement of toxic effects. The medicinal product is not intended for use in productive animals.
Measures of personal prevention
People with hypersensitivity to the components of the drug should avoid direct contact with Onsior tablets. In case of accidental contact of the medicinal product with the skin or mucous membranes, they should be washed immediately with plenty of water. It is forbidden to use empty containers from under the drug for domestic purposes; it must be disposed of with household waste. When using Onsior tablets, you should follow the general rules of personal hygiene and safety precautions provided for when working with drugs. Do not smoke, drink or eat while working. At the end of work, wash your face and hands thoroughly with soap.
Onsior tablets in the manufacturer’s closed packaging in a place protected from direct sunlight, away from food and feed, at a temperature of 0°C to 25°C. Keep out of the reach of children. The unused medicinal product is disposed of in accordance with the requirements of the legislation. The shelf life of the medicinal product, subject to storage conditions in the manufacturer’s unopened packaging, is 4 years from the date of manufacture. It is forbidden to use Onsior tablets after the expiration date.
MANUFACTURER: ELANCO
I. General information
Trade name of the drug: Onsior tablets (Onsior tablets).
International nonproprietary name: robenacoxib.
Pharmaceutical form: pills for oral use.
Onsior contains robenacoxib as an active substance.
The drug is produced in two modifications:
Onsior tablets for cats containing robenacoxib - 6 mg/tablet.
Onsior tablets for dogs in 4 doses containing robenacoxib: 5 mg/tab., 10 mg/tab., 20 mg/tab. or 40 mg/tablet.
As auxiliary substances, the Onsior preparation contains: yeast, microcrystalline cellulose, identical beef flavoring (in "Onsior tablets for dogs"), powdered cellulose (in "Onsior tablets for dogs"), povidone (K-30), crospovidone, anhydrous silicon dioxide and magnesium stearate.
In appearance, the drug is round tablets from beige to brown in color.
Onsior tablets for cats and Onsior tablets for dogs 5 mg are imprinted NA on one side and imprinted AK on the other side;
Onsior Tablets for Dogs 10 mg - Imprint NA on one side and Imprint BE on the other side, Onsior™ Tablets for Dogs 20 mg - Imprint NA on one side and Imprint CD on the other side and Onsior™ Tablets for Dogs 40 mg - Imprint NA on one side side to side and TSK print on the other side.
The shelf life of the medicinal product, subject to compliance with the conditions of storage in the closed packaging of the manufacturer, is 4 years from the date of manufacture.
It is forbidden to use Onsior tablets after the expiry date.
Onsior tablets for cats are available in packs of 6 tablets in blisters made of aluminum foil, placed in 1, 2, 5 or 10 pieces in cardboard packs together with instructions for use.
Onsior tablets for dogs are available in packs of 7 tablets in blisters made of aluminum foil, 1, 2, 4 or 10 pieces are placed in cardboard packs together with instructions for use. food and feed, at a temperature from 0°C to 25°C in places inaccessible to children.
II. Pharmacological properties
Onsior tablets belong to non-steroidal anti-inflammatory drugs.
Robenacoxib, included in the drug, is a non-steroidal anti-inflammatory agent of the coxib group, is a selective specific inhibitor of COX-2 and has anti-inflammatory and analgesic effects.
COX is presented in two forms: COX-1 – the constitutive form of the enzyme – performs protective functions, including in the gastrointestinal tract and kidneys; COX-2, the inducible form of the enzyme, is responsible for the production of mediators, including PHEg, that cause pain, inflammation, and fever.
When administered orally, robenacoxib is rapidly absorbed in the intestine, entering the systemic bloodstream and most organs and tissues; more than 99% of robenacoxib is bound to plasma proteins. Its maximum concentration in plasma is noted after 0.5 hours, bioavailability is 49% in cats and 62% in dogs when using tablets with food and 84% without food. Robenacoxib is metabolized in the liver, excreted mainly with bile (about 70% in cats and about 65% in dogs) and partially - with urine; the elimination half-life from the body of dogs is about 1.2 hours, cats - 1.7 hours.
According to the level of impact on the body, Onsior belongs to moderately dangerous substances.
III. Application procedure
Onsior tablets are prescribed to dogs and cats as an anti-inflammatory and pain-relieving drug for inflammatory and pain syndromes of various origins, including acute and chronic diseases of the musculoskeletal system (arthritis, arthrosis, synovitis, dislocations), inflammatory diseases of soft tissues, and also as an anti-inflammatory drug in the postoperative period.
It is forbidden to use Onsior for animals in a state of dehydration, hypovolemia and hypotension, as well as for animals weighing less than 2.5 kg. In case of extreme need, the prescription of a medicinal product to such animals is carried out under the constant supervision of a veterinarian.
Contraindication to use is the individual increased sensitivity of the animal to the components of the drug.
The drug should not be used in animals with severe heart, kidney and liver failure.
It is recommended to give the drug separately from feeding, but if necessary, the drug can be given together with food. Tablets should not be crushed or broken.
Onsior tablets are used in cats during surgery 30 minutes before anesthesia in a dose of 1-2.4 mg per 1 kg of the animal's weight; treatment can be continued for a period of up to 2 days after surgery; for diseases of the musculoskeletal system, the drug is used for up to 6 days.
Onsior tablets for dogs are used 30 minutes before or after feeding in a dose of 1-2 mg per 1 kg of animal weight. The course of treatment is determined by a veterinarian. As a rule, the duration
Onsior tablets are administered to dogs and cats and dogs individually once a day at the doses indicated in the table:
| 6 mg | 5 mg | 10 mg | 20 mg | 40 mg | |
| from 2.5 to 6 kg | 1 tab. | ||||
| from 6 to 12 kg | 2 tab. | ||||
| from 2.5 to 5 kg | 1 tab. | ||||
| from 5 to 10 kg | 1 tab. | ||||
| from 10 to 20 kg | 1 tab | ||||
| from 20 to 40 kg | 1 tab. | ||||
| from 40 to 80 kg | 2 tab. | ||||
Side effects
When using Onsior tablets in accordance with this instruction, side effects and complications in animals, as a rule, are not observed. Cats may experience gastrointestinal disturbances (vomiting, soft stools, or diarrhea) and these symptoms resolve spontaneously and do not require medication. With individual hypersensitivity of the animal to the drug and the appearance of allergic reactions, the use of the drug is stopped and the animal is prescribed antihistamines and symptomatic agents.
Contraindications
It is forbidden to use Onsior tablets in animals in a state of dehydration, hypovolemia and hypotension, as well as in animals weighing less than 2.5 kg. If it is absolutely necessary to prescribe a medicinal product to such animals, treatment is carried out under the constant supervision of a veterinarian. Contraindication to use is the individual hypersensitivity of the animal to the components of the drug. Do not use the drug in animals with severe cardiac, renal and hepatic insufficiency.
Special instructions
Onsior tablets should not be used simultaneously with other non-steroidal anti-inflammatory drugs and within 24 hours after their withdrawal, diuretics, as well as ACE inhibitors and other drugs with a high degree of binding to blood serum proteins due to the likelihood of mutual enhancement of toxic effects. The medicinal product is not intended for use in productive animals.
Measures of personal prevention
People with hypersensitivity to the components of the drug should avoid direct contact with Onsior tablets. In case of accidental contact of the medicinal product with the skin or mucous membranes, they should be washed immediately with plenty of water. It is forbidden to use empty containers from under the drug for domestic purposes; it must be disposed of with household waste. When using Onsior tablets, you should follow the general rules of personal hygiene and safety precautions provided for when working with drugs. Do not smoke, drink or eat while working. At the end of work, wash your face and hands thoroughly with soap.
Onsior tablets in the manufacturer’s closed packaging in a place protected from direct sunlight, away from food and feed, at a temperature of 0°C to 25°C. Keep out of the reach of children. The unused medicinal product is disposed of in accordance with the requirements of the legislation. The shelf life of the medicinal product, subject to storage conditions in the manufacturer’s unopened packaging, is 4 years from the date of manufacture. It is forbidden to use Onsior tablets after the expiration date.
MANUFACTURER: ELANCO