Indication
It is prescribed for the treatment and prevention of nematodes, cestodes and associative nematode-cestodes invasions caused by helminths of the following species: cestodes - Dipylidium caninum, Taenia spp., Echinococcus spp., Mesocestoides spp.; nematodes - Ancylostoma caninum, Toxocara canis, Toxocara leonina, Trichuris vulpis, Thelazia callipaeda; Angiostrongylus vasorum (Reduces the intensity of infection), Crenosoma vulpis (Reduces the intensity of infection), Dirofilaria immitis (disease prevention).
For dogs over 5 kg
Milprazon is a combined anthelmintic drug of nematicidal and cestocidal action. The active substances that are part of the drug determine its wide spectrum of anthelmintic action.
Composition: One tablet contains active ingredients:
Milbemycin oxime – 12.5 mg
Praziquantel 125 mg
Auxiliary components: microcrystalline cellulose, croscarmellose sodium, povidone, lactose monohydrate, colloidal silicon and magnesium stearate, meat flavoring, yeast powder
For small dogs and puppies up to 5kg
1 tablet contains active substances:
milbemycin oxime – 2.5 mg,
praziquantel – 25 mg.
Pharmacodynamics
Milprazon is a combined anthelmintic drug with nematocidal and cestocidal action. The active substances included in the composition of the drug determine its wide spectrum of anthelmintic action.
Milbemycin oxime is a macrocyclic lactone obtained as a result of fermentation of Streptomyces hygroscopicus, type Aureolacrimosus, active against larvae and adults of nematodes that parasitize in the alimentary canal of dogs, as well as against larvae of the nematode Dirofilaria immitis (microdirofilaria). The mechanism of action of milbemycin is determined by increasing the permeability of cell membranes for chlorine ions (Cl-), which leads to polarization of cell membranes of nerve and muscle tissue, paralysis and death of the parasite.
Praziquantel is an acylated pyrazinisoquinoline derivative. Praziquantel is active against cestodes and trematodes. By increasing the permeability of the parasite’s cell membranes for calcium ions (Ca2+), it causes membrane depolarization, muscle contraction and destruction of the tegument, which leads to the death of the parasite and facilitates its removal from the animal’s body.
Pharmacokinetics
After oral administration of the drug, the maximum concentration of milbemycin oxime in the blood plasma of dogs is reached within 2-4 hours, bioavailability is about 80%. It is excreted from the body of animals, mostly unchanged. Praziquantel, after oral administration in dogs, after taking a small portion of food, quickly reaches the peak level of the parent substance in the blood plasma (Tmax about 0.25-2.5 hours) and quickly decreases (t1/2 about 1 hour); the compound is quickly and almost completely biotransformed in the liver, the level of binding in plasma is about 80%, it is excreted from the body within 2 days with urine.
In rats, metabolism is complete but slow, as unchanged milbemycin oxime was not detected in urine or faeces. The main metabolites in rats are monohydroxylated derivatives associated with hepatic biotransformation. In addition to relatively high concentrations in the liver, there is some level of concentration in adipose tissue, which indicates the lipophilicity of the substance.
According to the degree of action on the body, Milprazone belongs to low-toxic substances (safety class 4), in recommended doses it does not show sensitizing, embryotoxic and teratogenic effects, it is well tolerated by dogs of different breeds and ages. The drug is toxic to bees, as well as to fish and other hydrobionts.
Dosage
The drug is administered to dogs once during feeding with a small amount of feed or is forcibly administered to the root of the tongue after feeding in a minimum therapeutic dose: 0.5 mg of milbemycin oxime and 5 mg of praziquantel per kg of body weight.
Depending on the body weight of the dog, the actual dosage is:
For dogs over 5 kg
| Body weight | Number of tablets |
| 5 – 25 kg | 1 tablet |
| >25 – 50 kg | 2 tablets |
| >50 – 75 kg | 3 tablets |
For small dogs and puppies up to 5kg
| Body weight | Number of tablets |
| 0.5 – 1 kg | 1/2 tablet |
| >1 – 5 kg | 1 tablet |
| >5 – 10 kg | 2 tablets |
A previous fasting diet and the use of laxatives before deworming is not required.
For the deworming of dogs with an infestation caused by Angiostrongylus vasorum, the drug Milprazon is used for therapeutic purposes four times with an interval of 7 days; for preventive purposes – every 4 weeks in a therapeutic dose. If concomitant treatment against cestodes is indicated, the drug can be replaced with a monovalent agent containing only milbemycin oxime.
For deworming of dogs with an infestation caused by Thelazia callipaeda, the drug is used twice with an interval of 7 days. If concomitant treatment against cestodes is indicated, the drug can be replaced with a monovalent agent containing only milbemycin oxime.
In order to prevent heartworm disease in disease-prone regions, the drug is used in the spring-summer-autumn period: before the beginning of the flight of mosquitoes and mosquitoes (intermediate hosts of D. immitis) once, then once every month and the last time in the season one month after the end of the flight of insects . Before deworming, it is necessary to consult a veterinarian to rule out the presence of microdirofilariae in the animal’s blood.
The specifics of the drug’s action during its first use and withdrawal have not been established.
When carrying out deworming, it is necessary to adhere to the recommended terms. In the case of skipping the next treatment, the use of the drug is resumed in the same dose and according to the same scheme.
Contraindication
Increased individual sensitivity of animals to the components of the drug (including in the anamnesis)!
Pronounced disorders of kidney and liver functions!
Do not use the drug for animals weighing less than 5 kg!
Do not apply to animals that are exhausted and sick with infectious diseases!
Reservation
Deworming of animals during pregnancy and lactation is carried out, if necessary, under the supervision of a veterinarian.
When using the drug, strictly follow the recommended dosage.
Dogs of the collie, bobtail, and sheltie breeds are sensitive to all anthelmintic drugs, so Milprazon should be used as necessary and under the supervision of a veterinarian. The tolerability of the drug in small puppies of this breed has not been studied.
Treatment of dogs with a high number of circulating microdirofilaria (Dirofilaria immitis) can lead to adverse reactions (pallor of mucous membranes, vomiting, muscle tremors, difficulty breathing or hypersalivation). These reactions are associated with the release of proteins of dead microfilariae and do not indicate direct toxicity of the drug. Treatment of microfilaremia in dogs (the presence of larvae in the blood) with Milprazone is not recommended.
In areas with a risk of heartworm disease or in cases where a dog is imported or exported from a risk area, it is necessary to consult a veterinarian before using the drug to exclude the disease. In the case of diagnosis of heartworm disease (Dirofilaria immitis), before using the drug, the animal is recommended to first use drugs against adult helminths.
For weakened and sick animals, the drug is used only under the supervision of a veterinarian with an assessment of the benefit/risk ratio.
Trematode infestation is atypical for dogs under 4 weeks of age, so the use of the combined drug Milprazon is not advisable.
Storage
The drug is stored in the manufacturer’s original packaging, separately from food and feed, in a dry place protected from direct sunlight, inaccessible to children and animals, at a temperature of 5 to 25°C. The halved tablets should be stored at a temperature of up to 25°C in the original blister. Store the blister in the outer cardboard packaging.
Expiration date
3 years. The shelf life of halved tablets after opening the original package is 6 months.
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