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MetKam 0.5% Solution  50 ml

MetKam 0.5% Solution 50 ml

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Metacam 0.5% (meloxicam) solution for injection, 50 ml
Trade name of the drug: Metacam® 5 mg / ml solution for injection (Metacam® 5 mg / ml solution for injection).

International non-proprietary name: meloxicam.

Metacam® 5 mg / ml solution for injection in 1 ml contains 5 mg of meloxicam as active substance, and as excipients – ethanol, polyethylene glycol, ethylenediaminetetraacetic acid and water for injections up to 1 ml.

Pharmacological properties
Pharmacotherapeutic group: non-steroidal anti-inflammatory drugs. Meloxicam, which is part of the drug, has pronounced anti-inflammatory and analgesic activity
The mechanism of action of meloxicam is to block the receptors responsible for the production of prostaglandin E, which is involved in the inflammatory process.
The drug penetrates well into the synovial fluid and the site of inflammation. Within 2-3 days of application, the concentration of meloxicam in the serum reaches a constant value. The concentration in synovial fluid is about 70% of the serum concentration. Meloxicam metabolites have no biological activity and are excreted in the faeces (75%) and urine (25%).
Metacam® 5 mg / ml solution for injection according to the degree of impact on the body belongs to moderately dangerous substances (hazard class 3 according to GOST 12.1.007-76), has no allergenic, embryotoxic, teratogenic and mutagenic effects.

Metacam is used to treat acute and chronic diseases of the musculoskeletal system in dogs, accompanied by severe pain and inflammation (fractures, traumatic arthropathy, sprains and ligaments, osteoarthritis, chronic degenerative joint disease, etc.), as well as to reduce postoperative pain.

The order of application
Metacam® 5 mg / ml solution for injection is used as an anti-inflammatory and analgesic drug:
On the first day – 0.4 ml / 10 kg of live weight
In the following days – 0.2 ml / 10 kg of live weight
At the beginning of therapy or as a single injection to eliminate acute and postoperative pain. Use for long-term treatment once a day for several days and, if necessary, up to 22 months.

Symptoms of overdose with the drug have not been established.

Features of action
Peculiarities of action at the beginning of the drug Metacam® 5 mg / ml solution for injection and its cancellation were not detected.
When using the drug Metacam® 5 mg / ml solution for injection in animals at the injection site may form a swelling that passes spontaneously.

The use of Metacam® 5 mg / ml solution for injection in animals with liver, cardiovascular, renal and hemorrhagic disorders, in case of hypersensitivity to the active substance is prohibited.

Features of application
If you miss a period of repeated use of Metacam® 5 mg / ml solution for injection, it is necessary to enter it in the prescribed dose as soon as possible.
Concomitant use of the drug with glucocorticosteroids, other nonsteroidal anti-inflammatory drugs and anticoagulants is prohibited.

Side effects
The most common and dangerous side effects of NSAIDs are lesions of the gastrointestinal tract, which are manifested by dyspepsia, gastric erosions, peptic ulcers and gastrointestinal bleeding. Two types of cyclooxygenases that inhibit NSAIDs were identified in the 1990s. The first enzyme, COX-1, is present in most tissues (in the endothelium of the stomach, kidneys, 1 platelets) and controls the production of prostaglandins with protective functions. The second, COX-2, is involved in the synthesis of prostaglandins, mediators of inflammation. COX-2 under normal conditions is absent and is formed during inflammatory reactions. Therefore, the anti-inflammatory effect of NSAIDs is due to the suppression of COX-2, and adverse reactions – the suppression of COX-1.
The ratio of NSAID activity in terms of blocking COX-2 and COX-1 allows us to judge their potential toxicity. The more intense the degree of inflammatory process, the more picky the action of Metacam on COX-1 and COX-2 and, accordingly, less toxic its effects on the body.

Personal prevention measures
When working with Metacam® 5 mg / ml solution for injection, the general safety requirements for handling animal medicines must be observed.
When working with the drug is prohibited to drink, smoke or eat. After finishing work, hands should be washed with warm soapy water.
In case of contact with eyes or mucous membranes, rinse immediately with clean water.

The drug is released packaged in glass vials, sealed with rubber stoppers, reinforced with aluminum caps.

Metacam® 5 mg / ml solution for injection is stored in a closed package of the manufacturer, separately from food and feed, in a dry, dark place at a temperature of 10 ° C to 25 ° C.
The drug should be stored out of reach of children.

Expiration date
Shelf life of Metacam® 5 mg / ml solution for injection under storage conditions – 2 years from the date of manufacture, after opening the bottle – no more than 28 days. The drug should not be used after the expiration date.