Gonali , (gonadorelin acetate) Solution for injection 30 ml (10ml*3pcs)
Composition
1 ml of the drug contains:
gonadorelin acetate - 0.05 mg
Description
The liquid is colorless, transparent, sterile.
Pharmacological properties
Gonadorelin acetate is a synthetic analogue of the polypeptide gonadotropin-releasing hormone of the hypothalamus, which causes increased secretion of gonadotropins by the pituitary gland, in particular follicle-stimulating hormone (FSH) and, to a greater extent, luteinizing hormone (LH), which is involved in the development and ovulation of follicles in the ovaries of female animals.
After injection, it is rapidly absorbed and reaches its maximum concentration in the blood plasma after 15-30 minutes. The half-life is 8-20 minutes. It is metabolized in the blood plasma, kidneys and liver, excreted mainly in the urine in the form of peptide fragments and amino acids.
Indications
Regulation of reproductive functions in farm and domestic animals.
Contraindications
Do not administer to animals with hypersensitivity to the active substance of the drug, during pregnancy, in acute diseases, as well as to exhausted animals and animals that have not reached sexual maturity.
Do not use together with other hormonal drugs.
Simultaneous use of human chorionic gonadotropic hormone hCG (HCG) can lead to ovarian hyperreaction.
Method of administration and dosage
The drug is used in the following doses per animal:
cattle (intramuscularly):
follicle persistence, ovulation delay - 2 ml, 2 hours before artificial insemination and 2 hours after it;
ovulation synchronization - 1 ml, after synchronization of estrus;
stimulation of ovarian function in the postpartum period - 1 ml, on the 12th day after calving;
treatment of ovarian (follicular) cysts of the ovaries — 2-3 ml;
estrous synchronization of insemination of cows in combination with cloprostenol according to the scheme:
1) injection of Gonalin — 2 ml;
2) injection of Broestrophan (0.5 mg of cloprostenol) — 2 ml, on the 7th day after the injection of Gonalin;
3) injection of Gonalin — 2 ml, 48 hours after the administration of cloprostenol.
Insemination of cows is carried out between the 8th and 24th hour after the second injection of Gonalin, regardless of the presence of visible signs of estrus.
pigs (intramuscularly or subcutaneously): synchronization of ovulation, increase in fertility — 0.5-1 ml (sows), 1-1.5 ml (replacement gilts);
Mares (intramuscular): no estrus, acyclic estrus, ovulation stimulation — 2 ml;
Females (intramuscular): ovulation stimulation — 0.5-1 ml, single dose.
Precautions
Do not mix with other pharmacological agents in the same syringe.
Personnel in contact with the drug must comply with the hygiene and safety rules adopted when working with veterinary drugs.
Meat and milk of animals that were administered the drug can be consumed by humans without restrictions.
Storage conditions
In a dry, dark place inaccessible to children at a temperature of +2 to + 20 °C.
After opening the bottle, store the drug in the refrigerator and use within 28 days.
Shelf life 2 years.
Manufacturer: Brovapharma Ukraine