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CIPRONORMA eye and ear drops  for Dogs and Cats (10ml - 0.33fl. oz)

CIPRONORMA eye and ear drops for Dogs and Cats (10ml - 0.33fl. oz)

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1 ml of the preparation contains active ingredients:
ciprofloxacin (in the form of ciprofloxacin hydrochloride) - 5 mg;
dexamethasone (in the form of dexamethasone sodium phosphate) - 1 mg.
Excipients: sodium hydroxide, lactic acid, benzalkonium chloride, trilon B, sodium chloride, water for injection.

Pharmacological properties

Combined preparations containing corticosteroids and antimicrobial agents. Dexamethasone and antimicrobial agents. ATX code S0ЗС A01.
CIPRONORM is a combined drug with pronounced antimicrobial and anti-inflammatory properties due to the action of ciprofloxacin and dexamethasone.
Ciprofloxacin belongs to the group of fluoroquinolones. The mechanism of action of ciprofloxacin consists in inhibiting bacterial DNA gyrase, thereby preventing the process of DNA replication, as well as in disrupting the integrity of the bacterial cell membrane, which leads to its death. Ciprofloxacin hydrochloride rapidly eliminates R-plasmids, which prevents the development of resistance of microorganisms to the drug.
The drug is active against gram-negative and gram-positive microorganisms, and especially against E. coli, Salmonella spp., Shigella spp., Enterobacter spp., Klebsiella spp., Proteus spp., Serratia spp., Campylobacter spp., Pseudomonas aeruginosa., Yersinia spp., Vibrio spp., Aeromonas spp., Haemophilus spp .; are also sensitive to the drug: Brucella spp., Staphylococcus spp. (including strains producing penicillinase and methicillin-resistant strains), Mycoplasma spp., Mycobacterium spp.
When instilled into the conjunctiva, the drug easily penetrates into all tissues of the eye, creating a stable therapeutic concentration. Ciprofloxacin penetrates well into the epithelium of the cornea and conjunctiva, while achieving a therapeutic concentration in the ophthalmic fluid.
When the drug is instilled into the ear, absorption of ciprofloxacin is insignificant. It is excreted in the urine.
Dexamethasone is a synthetic glucocorticosteroid with pronounced anti-inflammatory, antiallergic and antiexudative activity, with a rapid onset and short duration of action.
Dexamethasone stabilizes cell membranes, reduces the permeability of blood capillaries, exhibits an antiexudative effect by stabilizing the membranes of lysosomes.
When applied topically, systemic absorption is low. After instillation into the eyes, dexamethasone penetrates well into the epithelium of the cornea and conjunctiva; while in the ophthalmic fluid, therapeutic concentrations are observed; with inflammation or damage to the mucous membrane of the eye, the penetration rate increases. The duration of the anti-inflammatory action after the instillation of 1 drop of the solution is from 4 to 8 hours.
A small amount of dexamethasone enters the systemic circulation. Approximately 60-70% of dexamethasone entering the circulatory system binds to plasma proteins. Dexamethasone is metabolized in the liver under the action of cytochrome-containing enzymes, metabolites are excreted through the intestines. The half-life is on average 3 hours.

Treatment for dogs and cats:
with infectious and inflammatory diseases of the eyes and ears caused by microorganisms sensitive to ciprofloxacin;
with allergic processes of the anterior part of the eye, complicated by a bacterial infection;
for the prevention and treatment of inflammation of the eyes and ears in the postoperative period.

The drug is instilled into the conjunctival sac or ear canal 1-2 drops 2-3 times a day.
The duration of treatment is usually 5-7 days. If necessary, the duration of therapy can be extended up to 2 weeks.
In the presence of abundant purulent discharge, exudate, scabs, hygienic treatment of the eyes / external auditory canal is preliminarily carried out: 3-4 drops of the drug are instilled and the exudate is removed with gauze tampons (sterile tampons are used for the eyes). Then 1-2 drops of the drug are instilled.

Increased individual sensitivity to the components of the drug.

Use with caution in pregnant animals.
When applied, the drug should be at room temperature.
Shake well before use.

Release form
Polymer dropper bottles with a volume of 10 ml.

Store in a dark place, out of the reach of children, at a temperature of 5 ° to 25 ° C.
Shelf life is 2 years. After opening the bottle - 28 days, provided it is stored in a dark place at a temperature of 5 ° to 25 ° C.

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