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BromeT powder for Poultry, Dogs, Cats and Rabbits 100 g

BromeT powder for Poultry, Dogs, Cats and Rabbits 100 g

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Brometronide new powder, 100 g packet 

Compound

1 g of the drug contains:
tinidazole - 250 mg

Description
The powder is white or light yellow.

Pharmacological properties
Tinidazole is a synthetic antibiotic from the group of nitroimidazoles with a broad spectrum of action on the protozoa Balantidium coli, Entamoeba hyslolytica, Treponema hyodysenterie, Histomonas meleagridis, Lamblia intestinalis, Eimeria spp., Trichomonas columbae, T. Gallinae, bactericidal action on the anaerobes Bacteroides spp., Fusobacterium spp., Clostridium spp., most types of cocci - Streptococcus spp., Staphylococcus spp.
The mechanism of bactericidal action is the inhibition of DNA replication in bacterial and protozoan cells, which disrupts the synthetic and reparative processes of synthesis and leads to cell death.
After oral administration, tinidazole is rapidly and almost completely absorbed from the gastrointestinal tract. The maximum concentration in the blood serum is reached after 2 hours and persists for 12 hours. After absorption from the intestine, tinidazole is distributed throughout all tissues of the body, penetrates the blood-brain barrier, quickly reaching therapeutic levels. Approximately 12% is bound to plasma proteins.  Biotransformed in the liver and kidneys. The half-life from blood plasma is 12-14 hours. After 5 days, 60-65% of the drug is excreted in the urine, 12% in feces.

Indications
Treatment of animals with diseases caused by microorganisms sensitive to tinidazole:
poultry (pigeons, ornamental pheasants) - histomoniasis, trichomoniasis, eimeriosis, salmonellosis;
decorative rabbits - eimeriosis.

Contraindications
Do not administer to animals with hypersensitivity to tinidazole, with impaired liver and kidney function, and to females in the last third of pregnancy.

Directions for use and doses
The drug is used orally, pre-mixed with food.

Doses are:
ornamental poultry (pigeons, pheasants) - 0.1 g (25 mg of tinidazole) per 1 kg of body weight, which corresponds to 2 g of the drug (500 mg of tinidazole) per 1 kg of feed, daily, course - 10 days;
decorative rabbits:
adults - 0.2-0.3 g (50-75 mg of tinidazole) per 1 kg of body weight, daily, course - 3 days;
young animals during weaning from their mother - 0.1 g (25 mg of tinidazole) per 1 kg of body weight, daily, course - 10 days.

Cautions
With prolonged use of the drug, allergic reactions may occur (skin rashes, swelling, fever, urticaria, eosinophilia, etc.). When they appear, the use of the drug is stopped and antihistamines are prescribed. Use in large doses can cause intestinal dysbiosis. It disappears after stopping treatment with the drug.
When used simultaneously with cimetidine, the activity of the drug increases, and when used simultaneously with phenobarbital and rifampicin, it decreases.

Storage conditions
In a dry, dark place at a temperature from +8 to +25 °C.

Best before date
3 years.