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Bravosep Powder 100 gramm for Calves Pigs Lambs Rabbits Poultry

Bravosep Powder 100 gramm for Calves Pigs Lambs Rabbits Poultry

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Bravoseptol Powder 100 gramm for Calves Pigs Lambs Rabbits Poultry

1 g of the drug contains:
sodium sulfathiazole - 80 mg
sulfaguanidine - 70 mg
trimethoprim lactate - 38 mg
tylosin tartrate - 25 mg

Light yellow powder, poorly soluble in water.

Pharmacological properties
Combined broad-spectrum antibacterial drug.
Sulfathiazole and sulfaguanidine are antimicrobial bacteriostatic agents from the sulfonamide group. Sulfathiazole has a short-term effect, sulfaguanidine has a medium-duration effect.
Both sulfonamides are similar in their spectrum of properties and are active against gram-positive microorganisms - Clostridium perfringens, Bacillus anthracis, Corynebacterium diphtheriae, Actinomyces israelii, gram-negative - E. coli, Shigella spp., Klebsiella spp., Vibrio choleersia spp., Protozoa, Ch. Toxoplasma gondii, coccidia Eimeria stiedae.

The mechanisms of antimicrobial action of sulfathiazole and sulfaguanidine are also similar and are due to antagonism with para-aminobenzoic acid (PABA) and competitive inhibition of dihydropteroate synthetase. This leads to a violation of the synthesis of tetrahydrofolic acid, which is necessary for the synthesis of purines and pyrimidines, inhibits the growth of E. coli, reduces the synthesis of thiamine, riboflavin, niacin in the intestine.

Trimethoprim is a chemotherapeutic agent, which chemically is a derivative of diaminopyrimidine. It acts bacteriostatically against gram-positive microorganisms - Staphylococcus spp., Streptococcus spp., Clostridium spp., Corynebacterium spp., Gram-negative microorganisms - E. coli, Salmonella spp., Klebsiella spp., Proteus spp., Borteuretella spp.,. etc. The mechanism of action is associated with the inhibition of the enzyme dihydrofolate reductase in the synthesis of tetrahydrofolic acid. This leads to a deficiency in folate, a major cofactor in nucleic acid synthesis. As a result, the production of nucleic acids and protein in bacteria is disrupted. Bacterial dihydrofolate reductase is about 50,000 to 60,000 times more strongly bound by trimethoprim than by the corresponding mammalian enzyme. The effect manifests itself at the stage of folate synthesis, which occurs after the sulfonamides begin to act. Simultaneous use with sulfonamides enhances the inhibition of the production of tetrahydrofolic acid.

Tylosin tartrate is an antibiotic from the macrolide group. It is effective against gram-positive microorganisms - Corynebacterium spp., Clostridium spp., Erysipelothrix spp., Diplococcus pneumoniae, Staphylococcus aureus, some gram-negative microorganisms - Pasteurella spp., Vibrio spp., Le Brucespira spp., Neppus. , Rickettsia Rickettsia spp., Spirochaetales, Mycoplasma gallisepticum, M. synoviae, M. meleagridis. Tylosin acts bacteriostatically, inhibiting protein synthesis, due to irreversible connection with the 50S subunit of bacterial ribosomes. Stops the growth and reproduction of microbial cells, inhibits the synthesis of RNA in the ribosomes of bacterial cells at any stage of the ribosomal cycle.

Sulfathiazole is well absorbed from the gastrointestinal tract and acts systemically. Sulfaguanidine is almost not absorbed, which is why there is a high concentration in the intestine and the maximum effect is achieved in the treatment of gastrointestinal diseases. Sulfonamides penetrate well into tissues and body fluids, including pleural effusion, peritoneal and synovial fluids, middle ear exudate, chamber moisture, tissues of the urogenital tract, pass through the placenta and enter milk. Metabolized in the liver, mainly by acetylation to form microbiologically inactive, but toxic metabolites. Excreted by the kidneys approximately half unchanged (with an alkaline reaction of urine, excretion is enhanced), a small amount is excreted in the bile. With renal failure, the accumulation of sulfonamides and their metabolites in the body is possible, which causes a toxic effect.

When administered orally, tylosin is rapidly absorbed from the gastrointestinal tract and an hour later a sufficient bacteriostatic level is observed in the blood and tissues. Therapeutic concentrations of the drug remain in the blood serum for 6-8 hours. It is metabolized mainly in the liver and excreted unchanged mainly in the urine and partially in the feces, in laying birds - with eggs, in lactating animals - with milk.

The absorption of trimethoprim from the gastrointestinal tract occurs quickly and almost completely (90-100%), binding to plasma proteins - up to 70%. A high concentration of trimethoprim is observed in the secretions of the bronchial glands, prostate gland and bile. It crosses the placental barrier and enters milk. The half-life in blood plasma is 8-10 hours. 50-60% are excreted by the kidneys within 24 hours, mainly by glomerular filtration and tubular secretion, with 80-90% unchanged, the rest in the form of inactive metabolites, a small amount (4%) with bile.

Treatment of animals and poultry for diseases of the gastrointestinal tract, respiratory system and genitourinary system caused by microorganisms sensitive to the active ingredients of the drug:
calves under the age of 3 months - gastroenteritis, salmonellosis, pasteurellosis, vibriosis;
pigs - enzootic pneumonia, arthritis, dysentery, edema, erysipelas, salmonellosis, pasteurellosis;
lambs under the age of 3 months - septicemia, eimeriosis;
rabbits - gastroenteritis, colibacillosis, pasteurellosis, coccidiosis, pneumonia;
poultry (broiler chickens, turkeys, ducks, geese) - typhus, cholera, salmonellosis, mycoplasmosis, rhinitis.

Do not administer to animals with hypersensitivity to the active ingredients of the drug, impaired liver and kidney function, lactating and pregnant females.
Do not use in ruminants with functionally developed proventricles, in laying hens whose eggs are eaten by humans.
Do not use simultaneously with penicillins, cephalosporins, lincomycin, para-aminobenzoic acid and its compounds.

Method of administration and dosage
The drug is administered orally with food.
The daily dose of the drug for all animal species is 1.5-2 g per 10 kg of body weight (equivalent to 111-148 mg of sulfathiazole, 105-140 mg of sulfaguanidine, 44-58 mg of trimethoprim, 32-43 mg of tylosin). The calculated dose is given in two doses. At the first application, depending on the condition of the animal, the dose can be increased by 30-100%.
The treatment of pigs, poultry and rabbits is carried out mainly by the group method. To do this, the drug is thoroughly mixed with the daily rate of compound feed.
The following drug is added to 100 kg of compound feed:
pigs - 350-400 g;
poultry, rabbits - 400-450 g.
The course of treatment is 3-6 days.

With prolonged use of the drug, allergic reactions (skin rash, urticaria, itching), hepatitis, crystaluria, blood pathologies (leukopenia, agranulocytosis, thrombocytopenia) may occur.
In ruminants, the drug can inhibit the growth and reproduction of the symbiotic microflora of the rumen, which is involved in the synthesis of vitamins. Therefore, it is advisable to use B vitamins at the same time, do not limit animals in water and feed them with food rich in proteins and vitamins.
Some drugs, such as salicylates and phenylbutazone, can interfere with the binding of sulfonamides to blood plasma proteins and thereby increase the toxicity of sulfonamides. Derivatives of para-aminobenzoic acid, such as novocaine, tetracaine and procainamide hydrochloride, reduce the antimicrobial activity of sulfonamides.

Do not use with antibiotics that are antagonists of the constituents of the drug (chloramphenicol, monomycin, seporin, ristomycin, kanamycin).

After the last use of the drug, slaughter of animals and poultry for meat is allowed after 8 days. Meat obtained earlier than the specified period is disposed of or fed to unproductive animals, depending on the conclusion of the veterinarian.

Storage conditions
Store in a dry, dark place, out of the reach of children, at temperatures from +4 to +25 ° С.
Shelf life 2 years.

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