MARFLOXIN 10% VIAL 100 ML Solution for Injection (KRKA SLOVENIA) analog Marbocyl
Marfloxin 10% is a new generation of fluoroquinolones with excellent pharmacokinetic properties and a wide range of applications.
GENERAL INFORMATION
Trade name of the medicinal product: Marfloxin 10% solution for injection.
International non-proprietary name: marbofloxacin.
Dosage form: solution for injection. Marfloxin 10% solution for injection contains marbofloxacin 100 mg/ml as the active substance, and excipients - metacresol, disodium edetate, monothioglycerol, gluconolactone, water for injection. Marfloxin 10% solution for injection is produced packaged in hermetically sealed dark glass vials, sealed with rubber stoppers and rolled with aluminum caps and placed in cardboard boxes with instructions for use. The medicinal product should be stored in the manufacturer's packaging, separately from food and feed, in a dry, dark place, at a temperature of 5ºС to 25ºС. Do not freeze!
The shelf life of the medicinal product, if storage conditions are observed, is 2 years from the date of manufacture. After opening the bottle, the drug must be used within 28 days. It is forbidden to use the medicinal product after the expiration date. The drug should be stored in places inaccessible to children. Unused drug is disposed of in accordance with the requirements of the law.
PHARMACOLOGICAL PROPERTIES
Marbofloxacin belongs to the group of fluoroquinolones and has a broad spectrum of bactericidal action, based on the suppression of bacterial DNA replication. Marbofloxacin is active against gram-positive and gram-negative microorganisms, including Escherichia coli, Salmonella typhimurium, Campylobacter jejuni, Citrobacter freundii, Enterobacter cloacae, Serratia marcescens, Morganella morganii, Proteus spp, Klebsiella spp, Shigella spp, Pasteurella spp. also Mycoplasma spp. etc. After intramuscular and subcutaneous administration of the drug at a dose of 2 mg/kg, marbofloxacin is well absorbed from the injection site and penetrates into all organs and tissues of the body. Bioavailability is almost 100%. The maximum concentration of marbofloxacin, about 1.5 μg/ml, in plasma is reached after 1 hour. Marbofloxacin binds weakly to plasma proteins, in pigs - 10%, in cattle - 30%. The concentration of marbofloxacin in organs is higher than the concentration in blood plasma. The half-life in calves is 5-9 hours, in cattle with cicatricial digestion - 4-7 hours, in pigs - 8-10 hours. Marbofloxacin is excreted from the animal body mainly unchanged in urine and feces. With a single administration of the drug at a dose of 8 mg/kg of cattle, the maximum plasma concentration of 7.3 μg/ml is achieved after 0.78 hours. Binding to plasma proteins is approximately 30%, the half-life is 15.6 hours. Marfloxin 10% solution for injection is classified as a low-hazard substance in terms of its effect on the body.
INSTRUCTIONS FOR USE
Marfloxin 10% solution for injection is used for the treatment of cattle with respiratory diseases caused by marbofloxacin-sensitive strains of Pasteurella multocida, Mannheimia haemolytica and Histophilus somni and for the treatment of cows with acute mastitis caused by E. 10% solution for injection is used for the treatment of pigs with MMA syndrome.
A contraindication to the use of the drug Marfloxin 10% solution for injection is increased individual sensitivity of the animal to the components of the drug. The drug is not recommended for use in case of resistance of the pathogen strains to other fluoroquinolones.
Dosage
The drug is administered to animals once a day,
cattle - subcutaneously, intramuscularly or intravenously
pigs - intramuscularly, at a daily dose of 2 mg/kg (1 ml per 50 kg) of live weight of the animal. The duration of treatment
cattle is from 3 to 5 days,
pigs - 3 days.
A single use of Marfloxin 10% solution for injection in cattle intramuscularly at a dose of 8 mg/kg (2 ml per 25 kg) is possible.
The maximum volume of the drug for administration to one site should not exceed 20 ml. In case of overdose in animals, disturbances in the activity of the nervous system may be observed.
Treatment is symptomatic. The features of the drug's action during its first use and cancellation have not been established.
Skipping the next dose of the drug should be avoided, as this may lead to a decrease in therapeutic efficacy. If one dose is missed, the drug is resumed at the same dose and according to the same scheme.
When using the drug in the recommended dose, no side effects have been detected in pigs and cattle.
An inflammatory reaction may occur at the site of drug administration
It is not recommended to use Marfloxin 10% solution for injection simultaneously with chloramphenicol, macrolide antibiotics and tetracycline.
Withdrawal period
Slaughter of cattle for meat is allowed no earlier than 4 days, pigs - 2 days after the last use of the drug. The meat of animals forcibly killed before the end of the specified period can be used as feed for fur animals. Milk obtained from cows treated with Marfloxin 10% solution for injection is prohibited for food purposes during the treatment period and within 24 hours after discontinuation of the drug.
PERSONAL PRECAUTIONS
When working with Marfloxin 10% solution for injection, it is necessary to follow the general rules of personal hygiene and safety precautions provided for when working with drugs. People with hypersensitivity to marbofloxacin should avoid direct contact with the drug. In case of accidental contact of the drug with the skin or mucous membranes, it must be washed off with running water and soap. In case of allergic reactions and/or accidental ingestion of the drug into the human body, you should immediately contact a medical institution (have the instructions for use of the drug or the label with you).
The packaging from under the used drug is placed in a plastic bag and disposed of with household waste.
For use in veterinary medicine!
MANUFACTURER: KRKA SLOVENIA