Noroflox 10% (enrofloxacin) → analog Baytril Bayer
Description
Homogeneous, clear solution from light yellow to light brown.
Composition
1 ml contains active ingredient:
enrofloxacin 100 mg.
Excipients: up to 1 ml.
Pharmacological properties
The active ingredient of the drug – enrofloxacin, belongs to the fluoroquinolone group of antibiotics and has a broad spectrum of activity against gram-positive and gram-negative bacteria. Its mechanism of action is based on inhibition of bacterial gyrase enzyme, leading to disruption of bacterial DNA replication.
Enrofloxacin exhibits bactericidal activity against the following microorganisms: E. coli, Pseudomonas spp., Salmonella spp., Campylobacter spp., Haemophilus spp., Pasteurella spp., Bordetella spp., Erysipelothrix rhusiopathiae, Klebsiella spp., Proteus spp., Vibrio parahaemolyticus, Staphylococcus aureus, Streptococcus spp., Clostridium perfringens, Actinobacillus spp., Fusobacterium spp., Enterococcus spp. and others, as well as the detrimental effect on mycoplasmas (Mycoplasma spp.) and chlamydia (Chlamydia spp.).
After parenteral administration of enrofloxacin rapidly and completely absorbed due to high bioavailability. Its maximum concentration is reached after an average of 6 hours. Therapeutic concentration is maintained within 2 days. Enrofloxacin partially metabolized in the liver and excreted in the urine and bile.
Enrofloxacin has a high level of distribution. Thus, the concentration in the tissues and organs is usually higher than in serum. The bodies, which can be observed the highest concentration – the lungs, liver, kidneys, intestines.
The half-life depending on the type of animal is 2-7 hours.
Usege
Cattle: treatment of of diseases of the alimentary canal and respiratory system caused by organisms susceptible to enrofloxacin (colibacillosis, septicemia, pasteurellosis, salmonellosis, stafilokokoz, mycoplasmosis), secondary bacterial infections in viral diseases.
Pigs: treatment of of diseases of the alimentary canal and respiratory system caused by organisms susceptible to enrofloxacin (pasteurellosis, enzootic pneumonia, bacterial pneumonia, colibacillosis, septicemia, salmonellosis, MMA syndrome, atrophic rhinitis).
Dosage
Cattle drug is administered subcutaneously at a dose of 2.5 ml per 100 kg body weight (2.5 mg enrofloxacin per 1 kg of body weight) once a day. For the treatment of animals frequent respiratory infections and salmonellosis dose increased twice. The course of treatment is 3 days in salmonellosis – 5 days.
Pigs drug is administered intramuscularly at a dose of 2.5 ml per 100 kg body weight (2.5 mg enrofloxacin per 1 kg of body weight) once a day. For the treatment of animals frequent respiratory infections and salmonellosis dose increased twice. The course of treatment is 3 days in salmonellosis – 5 days at MMA-syndrome – 1-2 days.
Contraindications
Do not administer to animals with hypersensitivity to enrofloxacin.
Do not use the drug if found resistant strains of pathogenic bacteria resistant to quinoline.
Do not use concurrently with antibiotics tetracycline, chloramphenicol, cephalosporins and macrolides.
In combination with tetracycline, macrolides and chloramphenicol (chloramphenicol) may have antagonistic effects.
Do not administer to animals with central nervous system disorders, kidney damage and impaired growth cartilage.
Do not use horses.
Warning
Drugs from the group of quinolones should be used with caution in animals with CNS disorders.
If dose volume exceeds 5 ml for cattle and 2.5 ml for pigs, it must be divided and put into different areas.
The slaughter of animals for meat are allowed within 10 days after the last administration of the drug. Milk consumption in the food people are allowed after 7 days after the last administration of the drug. Received by the deadline meat and milk or dispose of unproductive animals are fed, according to a doctor of veterinary medicine.
Storage
Dry, dark, place inaccessible to children at temperature from 5 ° to 25 ° C.
The drug is stored separately from food, drink, including the animal feed.
Shelf life – 3 years.
After the first selection of the drug should be used within 28 days when stored in original packaging at temperatures between 5 ºC to 25 ºC.
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