{"product_id":"predsol-for-dogs-and-cats-20mg-20-tabs","title":"Predsol for dogs and cats 20mg 20 tabs","description":"\u003cp\u003e\u003cstrong\u003ePrednisolone tab. 0.5 g. 1 blister 20 tabs.\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003cbr\u003ePlano-cylindrical tablets with a score and a bevel, 0.5 g, from white to white with a cream tint.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eComposition\u003c\/strong\u003e\u003cbr\u003e1 tablet (0.5 g) contains the active ingredient: prednisolone - 20.0 mg. Excipients: microcrystalline cellulose, corn starch, lactose monohydrate, colloidal silicon dioxide, calcium stearate.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePharmacological properties\u003c\/strong\u003e\u003cbr\u003eATS vet classification code: QH02 - Corticosteroids for systemic use. QH02AB04 - Prednisolone.\u003c\/p\u003e\n\u003cp\u003ePrednisolone is a synthetic glucocorticosteroid of short action. It has anti-inflammatory, antiallergic, antishock, desensitizing, gluconeogenic, immunosuppressive and antiproliferative effects. Interacting with specific cytoplasmic receptors, it forms a complex that penetrates the nucleus and induces the formation of proteins, in particular enzymes that regulate various processes in cells.\u003c\/p\u003e\n\u003cp\u003eThe pharmacological action of prednisolone is carried out through the stabilization of cell membranes, inhibition of macrophage accumulation, reduction of leukocyte migration, reduction of capillary permeability, which prevents the formation of edema. Prednisolone inhibits phagocytosis, affects the metabolism of arachidonic acid, as well as the synthesis and release of inflammatory mediators. The immunosuppressive effect of prednisolone is due to the inhibition of the activity of T- and B-lymphocytes, a decrease in the content of complement in the blood, as well as inhibition of the production and effects of interleukin-2. It has a catabolic effect in lymphoid and connective tissues, muscles, adipose tissue, skin and bone tissue, increases the level of glucose in the blood. It exhibits some mineralocorticoid activity, increases the reabsorption of sodium and water ions in the renal tubules, increases the excretion of potassium and calcium ions from the body, especially when their levels in the blood plasma increase. Prednisolone inhibits the synthesis and secretion of adrenocorticotropic hormones by the pituitary gland and secondarily - glucocorticosteroids by the adrenal glands.\u003c\/p\u003e\n\u003cp\u003eCompared to hydrocortisone, the anti-inflammatory activity of prednisolone is 4 times greater, the mineralocorticoid activity is 0.6 times less.\u003c\/p\u003e\n\u003cp\u003ePrednisolone is rapidly absorbed from the gastrointestinal tract. It has high bioavailability. The time to reach maximum concentration in blood plasma is 1-2 hours. A significant part of prednisolone (90%) binds to cortisone-binding globulin - transcortin and albumin. It is metabolized in the liver, kidneys, small intestine, bronchi. Oxidized forms of prednisolone are glucuronized or sulfated. The half-life (T1\/2) is 2-4 hours. It is excreted by the kidneys mainly in the form of metabolites, up to 20% in unchanged form.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUse\u003c\/strong\u003e\u003cbr\u003eFor symptomatic treatment or as an adjuvant for the treatment of dogs and cats with inflammatory and immune-mediated diseases: pathologies of the musculoskeletal system; acute infectious and invasive diseases; allergic skin lesions; injuries and surgical operations.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDosage\u003c\/strong\u003e\u003cbr\u003eThe drug is administered orally once a day 15-30 minutes after feeding. The dose and total duration of treatment are determined by the veterinarian individually in each individual case, depending on the severity of the symptoms. It is necessary to use the lowest effective dose.\u003c\/p\u003e\n\u003cp\u003eInitial dose 0.5-2 mg of prednisolone (active substance) per kg of body weight per day. For long-term treatment: when the desired effect is achieved after a period of daily dosing, the dose should be reduced to the lowest effective dose. The dose should be reduced by administering every other day and\/or by halving the dose at intervals of 5-7 days until the lowest effective dose is reached.\u003c\/p\u003e\n\u003cp\u003eDogs should be treated in the morning and cats in the evening due to the difference in the daily rhythm.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eContraindications\u003c\/strong\u003e\u003cbr\u003eDo not use in cases of known hypersensitivity to the components of the product. Do not use in animals suffering from viral or fungal infections that are not controlled by appropriate treatment. It is not recommended to use the product in animals with diabetes, liver, kidney or heart failure, gastric and duodenal ulcers, bone fractures and osteoporosis, degenerative eye diseases and\/or corneal ulcers, hyperadrenocorticalism; in the presence of arterial hypertension, acute disorders of higher nervous activity, Itsenko-Cushing's syndrome; during pregnancy.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOverdose\u003c\/strong\u003e\u003cbr\u003eOverdose does not cause other side effects than those listed below (in the section Warnings. Side effects). The antidote is unknown. Signs of overdose should be treated symptomatically.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003eSide effects\u003c\/strong\u003e\u003cbr\u003eAnti-inflammatory corticosteroids such as prednisolone are known to have a wide range of side effects. Although single high doses are usually well tolerated, they can cause serious side effects with prolonged use. Dosage for medium and long-term use should usually be the minimum necessary to control symptoms.\u003cbr\u003eCushingoid symptoms may occur very commonly, including significant changes in fat, carbohydrate, protein and mineral metabolism, such as redistribution of body fat, muscle weakness and osteoporosis.\u003cbr\u003eBased on post-marketing experience and additional data, lethargy, diarrhoea and vomiting have been observed very rarely.\u003cbr\u003eDuring therapy, effective doses very often suppress the hypothalamic-pituitary-adrenal axis. After discontinuation of treatment, signs of adrenal insufficiency may occur, extending to atrophy of the adrenal cortex, which may result in the animal being unable to cope adequately with stressful situations.\u003cbr\u003eSystemic corticosteroids may rarely cause polyuria, polydipsia and polyphagia, especially in the early stages of therapy. Some corticosteroids may cause sodium and water retention and hypokalaemia with prolonged use. Systemic corticosteroids cause calcium deposits in the skin (cutaneous calcinosis).\u003cbr\u003eCorticosteroids may rarely delay wound healing and the immunosuppressive effect may reduce resistance to or exacerbate existing infections.\u003cbr\u003eGastrointestinal ulceration has been reported very rarely in animals treated with corticosteroids, usually in combination with non-steroidal anti-inflammatory drugs.\u003cbr\u003eSteroids may very rarely cause liver enlargement (hepatomegaly) with elevated serum liver enzymes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for use\u003c\/strong\u003e\u003cbr\u003eIn cases where bacterial infection is present, the product should be used in conjunction with appropriate antibacterial therapy.\u003c\/p\u003e\n\u003cp\u003eDue to the pharmacological properties of prednisolone, particular care should be taken when administering the veterinary medicinal product to animals with a weakened immune system.\u003c\/p\u003e\n\u003cp\u003eCorticosteroids such as prednisolone increase protein catabolism. Therefore, the product should be administered with caution to old or malnourished animals.\u003c\/p\u003e\n\u003cp\u003ePharmacologically active doses may lead to atrophy of the adrenal cortex, leading to adrenal insufficiency. This may become apparent particularly after discontinuation of corticosteroid treatment. Adrenal insufficiency may be minimized by administering therapy every other day, if possible. The dose should be reduced and withdrawn gradually to avoid the development of adrenal insufficiency.\u003c\/p\u003e\n\u003cp\u003eCorticosteroids such as prednisolone should be used with caution in patients with hypertension, epilepsy, previous steroid myopathy, immunocompromised animals and young animals, as corticosteroids may cause growth retardation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUse during pregnancy, lactation\u003c\/strong\u003e\u003cbr\u003eDo not use in pregnant animals. Studies in laboratory animals have shown that use in early pregnancy may cause foetal abnormalities. Use in late pregnancy may cause abortion or early parturition.\u003c\/p\u003e\n\u003cp\u003eGlucocorticoids are excreted in milk and may cause growth retardation in young animals. Use during lactation only according to the benefit\/risk assessment by the responsible veterinarian.\u003c\/p\u003e\n\u003cp\u003eInteraction with other medicinal products and other forms of interaction\u003cbr\u003ePhenytoin, barbiturates, ephedrine and rifampicin may accelerate the metabolic clearance of corticosteroids, leading to reduced blood levels and reduced physiological effect.\u003c\/p\u003e\n\u003cp\u003eConcomitant use of this veterinary medicinal product with non-steroidal anti-inflammatory drugs may lead to exacerbation of gastrointestinal ulcers. Since corticosteroids may reduce the immune response to vaccination, prednisolone should not be used concomitantly with vaccines or within two weeks of vaccination.\u003c\/p\u003e\n\u003cp\u003eThe use of prednisolone may cause hypokalaemia and therefore increase the risk of cardiac glycoside toxicity. The risk of hypokalaemia may be increased if prednisolone is used concomitantly with potassium-depleting diuretics.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions\u003c\/strong\u003e\u003cbr\u003eDo not vaccinate an animal being treated with a corticosteroid.\u003c\/p\u003e\n\u003cp\u003eSpecial precautions for persons and staff administering the product to animals\u003cbr\u003ePersonnel handling the product should observe the basic hygiene and safety rules adopted when handling veterinary medicinal products. Wash hands immediately and thoroughly after handling the product.\u003c\/p\u003e\n\u003cp\u003ePrednisolone or other corticosteroids may cause hypersensitivity (allergic reactions).\u003c\/p\u003e\n\u003cp\u003ePeople with known hypersensitivity to prednisolone or other corticosteroids or to any of the excipients should avoid contact with the veterinary medicinal product.\u003c\/p\u003e\n\u003cp\u003eIn case of accidental ingestion, especially by a child, seek medical advice immediately and show the package leaflet or label to the physician.\u003c\/p\u003e\n\u003cp\u003eCorticosteroids may cause foetal malformations; therefore, it is recommended that pregnant women avoid contact with the veterinary medicinal product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIncompatibilities (main)\u003c\/strong\u003e\u003cbr\u003eIs an insulin antagonist. Should not be used in combination with vaccines due to its immunosuppressive effect.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRelease form\u003c\/strong\u003e\u003cbr\u003e20 tablets in a blister, 1 blister in a pack.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003cbr\u003eIn a dry, dark place inaccessible to children at a temperature of 5 to 25 ° C. Shelf life - 2 years.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor use in veterinary medicine!\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eManufacturer: Ukrzoovetprompostach, Ukraine\u003c\/strong\u003e\u003c\/p\u003e","brand":"Tylosin Tylan Vet Store","offers":[{"title":"Default Title","offer_id":47202763702466,"sku":null,"price":27.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0518\/7230\/1250\/files\/6785.jpg?v=1773047462","url":"https:\/\/tylosintylan.com\/products\/predsol-for-dogs-and-cats-20mg-20-tabs","provider":"Tylosin Tylan Vet Store","version":"1.0","type":"link"}